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FDA Approves Expanded Use Of ISENTRESS® (raltegravir) In Combination Therapy For Adult Patients With HIV-1 Infection
Merck & Co., Inc. announced that the U.S. Food and Drug Administration (FDA) has approved an expanded indication for ISENTRESS®. The broadened indication now includes use in the treatment of adult patients starting HIV-1 therapy for the first time (treatment-naïve), as well as in treatment-experienced adult patients. ISENTRESS is used in combination with other antiretroviral (ARV) medicines for the treatment of HIV-1 infection in adult patients. The indication for ISENTRESS is based on analyses of plasma HIV-1 RNA levels through 48 weeks in three double-blind controlled studies. Two of these studies were conducted in clinically advanced, 3-class antiretroviral (NNRT, NRTI, PI) treatment-experienced adults and one was conducted in treatment-naïve adults. The safety and efficacy of ISENTRESS have not been established in pediatric patients. The use of other active agents with ISENTRESS is associated with a greater likelihood of treatment response.
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Mental Health

Women's First-trimester Working Conditions Impact Infant Birthweight

A new study shows that high levels of job strain during early pregnancy are associated with reduced birthweight and an increased risk of delivering a small-for-gestational-age (SGA) infant. A sample of 8,266 pregnant women in Amsterdam, Netherlands, completed a questionnaire gathering information on employment and working conditions. Researchers found that a workweek of 32 hours or more and high job strain were significantly associated with birthweight. The combination of high job strain and a long workweek resulted in the largest birthweight reduction and the highest risk of delivering an SGA infant. The study"s authors suggest, "Although pregnant women typically reduce their working hours or workloads at the end of their pregnancy, our results suggest that reducing job strain and working hours in the initial stages of pregnancy may be beneficial among women with stressful full-time jobs." American Journal of Public Health


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