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Also In Global Health News: Gaming For HIV Prevention; Sex Education In China; Concern Worldwide Receives Maternal, Child Health Grant
Video Game Teaches Kenyan Teens HIV Prevention
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Veterinarian Offers Advice On Evacuating With A Pet If Disaster Strikes
A veterinarian at Kansas State University"s College of Veterinary Medicine has advice for pet owners who want to consider how pets fit into their own household emergency plans -- especially if that includes evacuating.
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Federal Funding Should Be Available For Abortion Services, Opinion Piece Says
"The current debate over government funding for abortion in the health care plan is a reminder of how we have failed poor women," Frances Kissling writes in a Salon opinion piece. According to Kissling, the 32-year-old Hyde Amendment, which prohibits federal funding for abortion services, has played a large role in denying impoverished women access to the procedure. "Restoring those funds has not been a top priority for pro-choice advocates, who sadly concluded that because the public does not care about poor women and is actually hostile to poor women who have sex and become pregnant, it would be futile to put too much capital into reversing Hyde," Kissling writes.However, "we have an opportunity to make amends" by reversing the Hyde Amendment and restoring federal funding for abortion services, according to Kissling. "But the portents are not promising," she writes, adding that a group of "pro-life" Democrats in the House in a recent letter to House Speaker Nancy Pelosi (D-Calif.) "laid down the first major antiabortion challenge to health care reform." In addition, the Obama administration "has refused to rule out including abortion in the health care package, but President Obama is already signaling that the status quo on abortion is likely to endure," Kissling writes."The longer it takes to pass a plan, the more momentum against including coverage for abortion -- and possibly contraception -- will build," Kissling writes, adding that "there is a good chance there will be limits on government funding for abortions in the health care package, if not outright exclusion." A compromise being considered by the House Energy and Commerce Committee would not prohibit or require private insurers offering government plans from covering abortions but would prohibit the use of federal funds to pay for them. "Whether this would result in a reduction of coverage in such plans is unclear, but it is possible," she continues."The timing is critical. The need is great, and growing," Kissling writes, adding, "If abortion services are excluded from the health care reform package, the number of women who will not be able to afford abortions is bound to rise and the number of unwanted children will increase." Kissling concludes, "One hears over and over again that we all agree that the health care system is broken; the status quo is not acceptable. The status quo on coverage for abortion is especially unacceptable" (Kissling, Salon, 7/27).
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Strong Immune Response To New SiRNA Drugs In Development May Cause Toxic Side Effects

Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stimulates this undesirable immune activity, how to test for it, and how to design siRNA drugs to avoid it are critical topics explored in a timely review article published online ahead of print in Oligonucleotides, a peer-reviewed journal published by Mary Ann Liebert, Inc. siRNAs are duplex structures comprised of short oligonucleotide sequences. The discovery that naturally occurring and synthetic siRNAs can effectively prevent expression of a disease gene sparked intense interest in developing siRNAs as drugs. However, depending on the structure and sequence of a siRNA and how it is delivered, it may induce a potent innate immune response in humans, stimulating the release of inflammatory chemicals such as cytokines and interferons. Exploring the possibility of designing synthetic siRNAs and developing novel delivery methods that would exploit the drug-like capabilities of siRNA while preventing toxic side effects, researchers are working to understand the mechanism by which siRNA stimulates the immune system. In the article entitled, "siRNA and Innate Immunity," Marjorie Robbins, Adam Judge, and Ian MacLachlan, from Tekmira Pharmaceuticals (Burnaby, British Columbia, Canada), describe the different possible mechanisms for siRNA-mediated immune activation in various cell types, present preferable siRNA sequences and strategies for chemically modifying the siRNA to minimize its immunostimulatory effects, and suggest experimental methods for studying the safety of siRNA therapeutics. The authors conclude, "We are confident that through the judicious application of well-informed siRNA design and the use of increasingly effective delivery systems, demonstrations of systemic siRNA in human subjects will soon be realized." "This is perhaps the most comprehensive review on siRNAs and innate immunity to date and a must read for anyone using siRNAs therapeutically," says John Rossi, PhD, Co-Editor-in-Chief of Oligonucleotides and Professor in the Department of Molecular Biology, Beckman Research Institute of the City of Hope (Duarte, CA). Vicki Cohn Mary Ann Liebert, Inc./Genetic Engineering News


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