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Hospital Bedside Technology Solution Results In 74 Percent Reduction In Heart Failure Readmission Rate
A significant study was released today demonstrating the efficacy of Interactive Patient Care technology on improving outcomes in heart failure care.
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Importance Of 'Moral Values' Replaced By Economy, Health Care For Voters, Washington Post Columnist Says
Since the 2004 election, issues relating to the economic recession and health care have replaced "moral values" as the most important political topics in the U.S., columnist E.J. Dionne writes in a Washington Post opinion piece. He cites a survey released in May by the Pew Research Center that offered respondents the same list of issues that appeared on the 2004 exit poll and found that the importance of moral values had decreased by more than half. Dionne writes that concern over the economy and jobs had more than doubled on the survey, while issues such as health care and education also had "gained substantial ground." According to the survey, "The drop in concern over moral values was particularly sharp among older working-class voters who have been trending Republican for years," Dionne writes.According to Dionne, "Conservative moral values voters have become the heart of the Republican coalition, and if their ranks are shrinking, so is the GOP"s base." He writes that it "is no accident that President Obama takes every opportunity to shift the public debate to issues -- the economy, health care and education -- that the populist conservatives ... find appealing."According to Dionne, "[f]ew recent survey findings are more enlightening about what"s happening in American politics -- and what is likely to happen to the debate over the Supreme Court nomination of Judge Sonia Sotomayor." He adds that it is "striking that while some antiabortion groups issued stinging press releases against Sotomayor, her views on abortion remain a mystery -- to the consternation of abortion-rights supporters." According to Dionne, "Both sides in the abortion debate want to have a confrontation that Sotomayor may not give them the opportunity to stage." He adds that the "vast majority of Americans are not clamoring for this particular battle" (Dionne, Washington Post, 6/1).
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Genetically Elevated Levels Of Lipoprotein Associated With Increased Risk Of Heart Attack
A genetic analysis of data from three studies suggests that genetically elevated levels of lipoprotein(a) are associated with an increased risk of heart attack, according to a study in the June 10 issue of JAMA.
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Number Of Therapeutic Peptides In Clinical Study Has Nearly Doubled Since The 1990s, According To Tufts Center For The Study Of Drug Development

Since 2000, the number of therapeutic peptides in clinical study has nearly doubled the 1990s rate, due in part to advances in synthesis, delivery, and formulation technologies, according to a study recently completed by the Tufts Center for the Study of Drug Development. "Therapeutic peptides have emerged as a therapeutically and commercially important class of drugs and 48 are now on the market worldwide, with four having generated global sales of more than $500 million each in 2007," said Janice M. Reichert, senior research fellow at Tufts CSDD and author of the study. The average annual number of therapeutic peptides entering clinical study worldwide in the 2000-07 period nearly doubled, to 16.9 from 9.7 during the 1990s, the study found. Reichert said continued aggressive investing by the pharmaceutical industry in new therapeutic peptide product development is expected to continue at a strong pace for the foreseeable future. While generally not as convenient to administer as traditional, small-molecule pharmaceuticals, peptides, such as ziconotide and degarelix, offer the advantage of providing greater specificity in targeting the cause of an ailment. Physicians and patients also are becoming more accepting of peptide-based medicines. The Tufts CSDD study, aimed at eliciting a current picture of clinical development and approval trends for these products, done in cooperation with the Ferring Research Institute, examined data on 318 therapeutic peptide candidates that entered clinical study from the 1940s through October 2008. The study, reported in the May/June Tufts CSDD Impact Report, released today, also found that: - During 2000-07, new peptides entering clinical development were most frequently studied as treatments for metabolic (26%) indications, one of 15 therapeutic areas in which peptides were being developed. - Average total clinical study and U.S. Food and Drug Administration review time for new therapeutic peptides was 10.8 years, 2.6 years longer than the combined average clinical study and review time for all drugs approved in the U.S. in 1993-07. - Efficacy issues and commercial considerations were most often cited as reasons for discontinuing clinical studies of new therapeutic peptides. Tufts Center for the Study of Drug Development


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