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ImmunoGen Announces Encouraging New Clinical Data With The Company's IMGN901 Compound In The Treatment Of Small-Cell Lung Cancer
ImmunoGen, Inc. (Nasdaq: IMGN), a biopharmaceutical company that develops targeted anticancer therapeutics using its Targeted Antibody Payload (TAP) technology, today announced the presentation of encouraging initial efficacy, safety and tolerability clinical data with its IMGN901 product candidate in the treatment of small-cell lung cancer (SCLC). In two early-stage clinical trials that enrolled patients whose SCLC had recurred following treatment with standard chemotherapies, IMGN901 administration achieved notable tumor shrinkage and/or sustained stable disease. The compound also demonstrated encouraging activity against other CD56-expressing (CD56+) solid tumors. These clinical data are being presented at the 13th World Conference on Lung Cancer taking place in San Francisco, CA, from July 31 to Aug. 4, 2009.
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American Lung Association Applauds EPA For Taking Critical Steps To Protect Public Health From Global Shipping Pollution
Statement of Captain Charles D. Connor, U.S. Navy (Ret.), American Lung Association President and CEO:
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Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression And Cell Type Specificity
Bionovo, Inc. (Nasdaq: BNVI) announced that a study of the gene regulation in multiple cell lines by several of their estrogen receptor beta (ERb) candidates will be published in Public Library of Science One.
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In Human-Dog Communication, Breed Is As Important As Species

Dog breeds selected to work in visual contact with humans, such as sheep dogs and gun dogs, are better able to comprehend a pointing gesture than those breeds that usually work without direct supervision. A series of tests, described in BioMed Central"s open access journal Behavioral and Brain Functions, should caution researchers against making simple generalizations about the effects of domestication and on dog-wolf differences in the utilization of human visual signals. Mç¡rta Gç¡csi, from Eç¶tvç¶s University, Hungary, worked with a team of researchers to examine the performance of different breeds of dogs in making sense of the human pointing gesture. Gç¡csi said, "It has been suggested that the study of the domestic dog might help to explain the evolution of human communicative skills, because the dog has been selected for living in a human environment and engaging in communicative interactions with humans for more than 10,000 years. However, this study is the first to reveal striking difference in the performance of breed groups selected for different characteristics." The researchers found that gun dogs and sheep dogs were better than hunting hounds, earth dogs (dogs used for underground hunting), livestock guard dogs and sled dogs at following a pointing finger. They also out-performed mongrels. Moreover, breeds with short noses and centrally placed eyes were better at interpreting the gesture than those with long noses and widely spaced eyes, which can probably be connected to a more optimal retinal location of greatest visual acuity, that might help focus their attention. According to Gç¡csi, "Although these results may appear to be unsurprising, there is a common tendency to make assumptions about genetic explanations for differences in comprehension between "dogs" and wolves. Our results show that researchers must be careful to control for animal breed when carrying out behavioral experiments." Notes: Effects of selection for cooperation and attention in dogs Marta Gacsi, Paul McGreevy, Edina Kara and Adam Miklosi Behavioral and Brain Functions (in press) http://www.behavioralandbrainfunctions.com/ Graeme Baldwin BioMed Central


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