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Genetic Factors May Predict Depression In Heart Disease Patients
Individuals with heart disease are twice as likely to suffer from depression as the general population, an association the medical community has largely been unable to explain. Now, a new study by researchers at The Miriam Hospital, in conjunction with The Montrçİal Heart Institute, University of Montrçİal and McGill University, reveals there may be genetic variations that contribute to depression in heart disease patients.
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Diagnostic Evaluation Of PSA Recurrence And Review Of Hormonal Management After Radical Prostatectomy
UroToday.com - At present, no consensus exists on how patients with PSA recurrence after radical prostatectomy (RP) should be treated. Although patients with postoperative PSA recurrence frequently undergo androgen deprivation therapy (ADT) before evidence of metastatic disease, the benefit of this approach is uncertain. As no randomized studies are performed in this clinical setting there is no conclusive evidence that hormone therapy (HT) after RP will prolong survival or reduce morbidity.
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GTCbio Announces Its 4th Annual Assay Development And Screening Technologies Conference Taking Place On June 8-9, 2009 In San Francisco
GTCbio Announces 4th Annual Assay Development and Screening Conference taking place June 8-9, 2009. As compounds derived from high throughput screening increasingly find their way into clinical trials, drug screening has become widely accepted as a critical step in the drug discovery process. After more than a decade of rapid growth, tremendous progress has been made in assay technology, laboratory automation, and informatics. These technological developments have not only facilitated a drastic increase in throughput and efficiency in drug screening, but have also provided novel solutions in other areas of drug discovery and development. As screening has also become prominent in biological research, screening facilities have become increasingly popular in academic institutions.
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Gene Hunters Target Child Kidney Failure

Researchers are zeroing in on the genetic abnormalities predisposing to vesicoureteric reflux (VUR), one of the most common causes of urinary tract infections and kidney failure in children, reports a study in an upcoming issue of the Journal of the American Society of Nephrology (JASN). "In this study, we accomplished a very critical step towards the identification of the VUR gene," says Ali G. Gharavi, MD (Columbia University, New York). Led by Patricia L. Weng, MD (Mount Sinai School of Medicine), and Simone Sann-Cherchi, MD (Columbia University), the researchers, including Gharavi, performed genetic studies in 16 large families affected by VUR. "In VUR, a faulty valve in the bladder allows urine to flow back, or "reflux," up to the kidneys," Gharavi explains. If VUR persists, it can lead to repeated urinary tract infections and kidney failure. It affects about one percent of children and runs in families. A method called linkage analysis was used to pinpoint the location of the abnormal genes associated with VUR. "We narrowed down the location of the VUR susceptibility gene to a region on chromosome 12 that is less than one percent of the entire genome," says Gharavi. In contrast to previous studies, the VUR susceptibility gene appeared to be inherited in autosomal recessive fashion affected children inherit one copy of the faulty gene from each parent. According to Gharavi, "This means that there are many different inherited forms of VUR, some with dominant and some with recessive inheritance." The next step will be conducting studies to identify the exact gene predisposing to VUR. "We plan to study more families and other patients with VUR so that we can better understand how the kidney and urinary tract develop and then create better diagnostic tests and treatments," Gharavi adds. Although the study does not identify the gene causing VUR, it represents the initial, critical step towards achieving that goal. The study was limited to a specific group of Caucasian patients; more research will be needed to determine whether the results apply to other populations and ethnicities. The authors reported no financial disclosures. The research was supported by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Kidney Foundation, and the Telethon Institute. Founded in 1966, the American Society of Nephrology (ASN) is the world"s largest professional society devoted to the study of kidney disease. Comprised of 11,000 physicians and scientists, ASN continues to promote expert patient care, to advance medical research, and to educate the renal community. ASN also informs policymakers about issues of importance to kidney doctors and their patients. ASN funds research, and through its world-renowned meetings and first-class publications, disseminates information and educational tools that empower physicians. American Society of Nephrology (ASN)


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