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Families Of Sudden Unexplained Death Victims Should Receive Comprehensive Cardiogenetic Testing
Relatives of a young person who dies suddenly should always be referred for cardiological and genetic examination in order to identify if they too are at risk of sudden death, a scientist told the annual conference of the European Society of Human Genetics. Dr. Christian van der Werf, a research fellow at the Department of Cardiogenetics, Academic Medical Centre, Amsterdam, The Netherlands said that, although his team"s research showed that inherited heart disease was present in over 30% of the families of sudden unexplained death (SUD) victims, the majority of such relatives were currently not being referred for examination.
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Study Gives Clue To How Mothers' Brains Screen For Baby Calls
Emory University researchers have identified a surprising mechanism in the brains of mother mice that focuses their awareness on the calls of baby mice. Their study, published June 11 in Neuron, found that the high-frequency sounds of mice pups stand out in a mother"s auditory cortex by inhibiting the activity of neurons more attuned to lower frequency sounds.
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State Medicaid Coverage, Costs Grow In Maryland, Mississippi
"A year into a new effort to expand health coverage, recession-weary Marylanders are flocking to the state"s Medicaid program in numbers far greater than expected, costing the state $50 million more in the process," The Baltimore Sun reports. "As of this week, 44,255 additional state residents had enrolled in Maryland"s Medicaid system after income limits were significantly relaxed, outpacing projections that enrollment would increase by 26,605." Health advocates say "the state is doing the right thing by expanding publicly funded health care to adults who have children," but "increased enrollment has also enlarged the price tag." And "while the federal government picks up half the cost, the higher expenses come as Maryland is battling severe budget shortfalls. State health spending has been propped up this year by a major influx of stimulus dollars. Proponents had hoped to extend the public plan to adults without children this year, but the initiative was a victim of state budget constraints" (Fisher, 7/2).
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ExonHit Announces Last Patient Out For EHT 0202 Phase IIa Study In Alzheimer's

ExonHit Therapeutics (Paris:ALEHT) announced that clinical testing of EHT 0202, its lead therapeutic compound in Alzheimer"s disease, is progressing well. Final patient dosing for the Phase IIa proof-of-concept clinical trial assessing EHT 0202 in patients with Alzheimer"s disease is completed. "In light of the neuroprotective and procognitive effects demonstrated by EHT 0202 in preclinical studies, we believe that our drug candidate has the potential to modify the course of Alzheimer"s disease and might open a new era in the treatment of this devastating disease," commented Dr. Loö¯c Maurel, President of the Management Board of ExonHit Therapeutics. "We look forward to the outcome of this Phase IIa trial and are planning to initiate out-licensing discussions with potential partners next fall." Top-line data from the EHT 0202/002 Phase IIa study will be presented at the 13th Congress of the European Federation of Neurological Societies on September 14th in Florence, Italy. The study was conducted in 23 centers across France under the supervision of Professor Bruno Vellas, Head of Alzheimer"s Disease Clinical Research Center and Gerontopole, Toulouse University Hospital, France. A total of 197 ambulatory patients suffering from mild to moderate Alzheimer"s disease were selected and 158 of them were randomized to receive oral study treatment over a three-month period. This multicenter, randomized, double-blind, placebo-controlled study was designed to assess the safety and tolerability, as a primary objective, and also exploratory efficacy of EHT 0202 in patients with Alzheimer"s disease. The effect of two different doses of EHT 0202 (either 40 or 80 mg twice a day) as adjunctive therapy to one acetylcholinesterase inhibitor is evaluated in comparison to placebo. Efficacy is evaluated on multiple parameters by using different scales, including a battery of cognitive assessment tests (ADAS-Cog, NTB, MMSE), assessment of patients" daily living activities, and also global behavioural assessment. About EHT 0202 EHT 0202 has a novel mechanism of action when compared to existing Alzheimer"s disease therapeutics: it stimulates the í±-secretase pathway, thus enhancing the production of the procognitive and neuroprotective sAPPí± fragment of APP (Amyloid Precursor Protein). The stimulation of the í±-secretase pathway being to the detriment of Aí² amyloid peptide production, EHT 0202 potentially reduces toxic Aí² plaque formation (1). Phase I studies demonstrated good tolerability of EHT 0202 in both young and aged healthy volunteers; importantly, no sedation was observed clinically. Preclinical studies have shown that EHT 0202 protects cortical neurons against Aí²42-induced stress and that this neuroprotection is associated with sAPPí± induction. EHT 0202 has also demonstrated pro-cognitive properties in several animal models: age-related memory impairment and scopolamine-induced amnesia (2). About Alzheimer"s disease Alzheimer"s disease is a progressive neurodegenerative condition that is the most frequent cause of dementia in the aging population. An estimated 26.6 million people worldwide had Alzheimer in 2006. This number is anticipated to quadruple by 2050 to more than 100 million; 1 in 85 persons worldwide will be living with the disease (3). In France alone, 800,000 people, or 18% of people above 75 years old, have Alzheimer"s disease (4). References (1) Marcade M, Bourdin J, Loiseau N, Peillon H, Rayer A, Drouin D, Schweighoffer F, Desire L. Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing. Journal of Neurochemistry. 2008; 106: 392-404 (2) Pando M, Marcade M, Peillon H, Rayer A, Drouin D, Desire L. An alpha-secretase stimulator drug for cognitive disorders associated with neurodegeneration. Presented at the 12th congress of the European Federation of Neurological Societies; 23-26 August, 2008; Madrid, Spain (3) Brookmeyer R, Johnson E, Ziegler-Graham K, MH Arrighi (July 2007). "Forecasting the global burden of Alzheimer"s disease". Alzheimer"s and Dementia 3 (3): 186-91 (4) Plan Maladie d"Alzheimer 2004-2007- Ministö¨re des solidaritö©s, de la santö© et de la famille ExonHit Therapeutics


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