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Novel Handheld Device Detects Anthrax With Outstanding Accuracy And Reliability
Veritide Ltd., a developer of innovative biological identification and detection solutions, today reported that new independent data to be presented at the Biodetection Technologies 2009 conference confirm the exceptional accuracy of its Ceeker™ (pronounced "seeker") portable bacterial detection device in discriminating between anthrax spores and similar-looking hoax substances. The data show that in over two weeks of testing at the Midwest Research Institute in Florida, the company"s Ceeker scanner accurately identified 100% of the anthrax samples used and was correct in 95% of tests involving hoax substances. These test results are consistent with similar results produced last year by a New Zealand forensic testing agency, Environmental Science and Research (ESR).
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Large African American Study May Lead To Treatment And Prevention Of Hypertension
Researchers from the Coriell Institute for Medical Research and the National Human Genome Research Institute (NHGRI) have announced the discovery of five sites of variation in the genome that are associated with blood pressure in African Americans.
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Scientists Follow Live Infection By Food-poisoning Bacteria Listeria
Scientists in Portugal and France managed to follow the patterns of gene expression in food-poisoning bacteria Listeria monocytogenes (L. monocytogenes) live during infection for the first time. The work about to be published in PLoS Pathogens shows how the bacterial genome shifts to better adapt to infection by activating genes involved in virulence and subversion of the host defences, as well as adaptation to the host conditions. This is the first time that the molecular interactions between L. monocytogenes and its host, as they occur during the different steps of infection, are followed in real time paving the way, not only to the development of new therapies against this potentially lethal bacterium, but also for the study of other pathogen/host interactions.
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A Link Between The Circadian Rhythm And Salt Balance

New research, conducted by Charles Wingo and his colleagues, at the University of Florida, Gainsville, suggests a link between the circadian rhythm and control of sodium (salt) levels in mice. The hormone aldosterone regulates levels of sodium in the blood and thereby helps control blood pressure. Although it is known that aldosterone regulates sodium levels by controlling expression of the alpha-subunit of the epithelial sodium channel (alpha-ENaC) in the kidney, the molecular pathway by which aldosterone modulates alpha-ENaC levels has not been determined. In a previous study to address this issue, Wingo and colleagues found that aldosterone induced expression of the circadian clock gene Per1 in mouse cells, but the effects of this induction were not investigated. In this new study, they have revealed that the protein produced from the Per1 gene (Period 1) regulates expression of alpha-ENaC in the mouse kidney. Importantly, in the absence of Period 1, expression of alpha-ENaC in the mouse kidney was decreased and sodium loss in the urine was increased. Since expression from the Per1 gene seemed to follow a circadian pattern, the authors suggest that the circadian clock has a role in balancing sodium levels in the body. TITLE: The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice Karen Honey Journal of Clinical Investigation


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