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Study May Aid Efforts To Prevent Uncontrolled Cell Division In Cancer
Researchers from the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine have uncovered a remarkable property of the contractile ring, a structure required for cell division. Understanding how the contractile ring works to divide the cell may facilitate development of therapies to prevent uncontrolled cell division in cancer.
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'Consumer-Directed' Plans Rise In Popularity As Businesses Scramble To Cut Health Costs
High-deductible health insurance plans coupled with health savings accounts (tax-advantaged funds for covering medical costs), are becoming the plan of choice for Connecticut"s small businesses newly offering insurance to employees, Hartford Business reports. The plans, called "consumer-directed health plans," make up 60 percent of the insurance company Aetna"s new small business sales. Nationally, the number of people with these plans rose from 3.2 million in 2006 to eight million this year.
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The Dawn Of A New Era In Cancer Treatment
A new article in Scrip World Pharmaceutical News highlights enormous change in cancer medicine with highly personalised treatments, patient top-up payments in some markets, response-related payments and even refunds when there is no response to a treatment, all driving the future of cancer care worldwide.
Oncology

A Breakthrough In Gastric Carcinogenesis

Checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In gastric cancer, CHFR promoter hypermethylation has been reported to lead to chromosome instability (CIN) and genetic instability is one of the hallmarks of human cancer. A research team led by Dr Eiji Oki from Kyushu University examined the methylation status of the promoter region of CHFR and microsatellite instability (MIN) status in primary gastric cancers. Their study was published on May 28, 2009 in the World Journal of Gastroenterology. They investigated the promoter methylation of CHFR in 59 cases of gastric cancer using methylation-specific PCR. Five microsatellite loci were analyzed using high-intensity microsatellite analysis reported previously, and p53 gene mutations were investigated by direct sequencing. They found that twenty cases (33.9%) showed promoter methylation and no relation was observed with the clinicopathological factors. The promoter methylation of CHFR was frequently accompanied with MIN. Seven of 20 (35.0%) cases showed MIN in hypermethylation of the CHFR tumor, while three of 39 (7.7%) cases showed MIN in the non-methylated CHFR tumor (P World J Gastroenterol 2009; 15(20): 2520-2525. Correspondence to: Eiji Oki, MD, PhD, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Lai-Fu Li World Journal of Gastroenterology


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